Polyozellin, a new inhibitor of prolyl endopeptidase from Polyozellus multiplex.
نویسندگان
چکیده
Korea Research Institute of Bioscience and Biotechnology, KIST, P. O. Box 115, Yusong, Taejon 305-600, Korea f Dept. of Agricultural Chemistry, College of Agriculture, Kyungpook National University, 1370, Sankyuk-Dong, Taegu 702-701, Korea ft Department of Microbiology, College of Natural Sciences, Pusan National University, Pusan 609-735, Korea m The Institute of Physical and Chemical Research (RIKEN), Hirosawa 2-1, Wako, Saitama 351-01, Japan
منابع مشابه
Kynapcin-12, a new p-terphenyl derivative from Polyozellus multiplex, inhibits prolyl endopeptidase.
composedof a portion of the transmembrane domain and the extracellular domain of the amyloid precursor protein (APP)2). The neurotoxicity of the A/3 has been detected in several cell systems, including primary cultured neurons3). The A/3 having an alanine C-terminus is derived from the proteolytic cleavage of the APPby the action of the yet unidentified endoproteolytic enzymes, /3and y-secretas...
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Thelephoric acid is an antioxidant produced by the hydrolysis of polyozellin, which is isolated from Polyozellus multiplex. In the present study, the inhibitory effects of polyozellin and thelephoric acid on 9 cytochrome P450 (CYP) family members (CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4) were examined in pooled human liver microsomes (HLMs) using a cocktail p...
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Purpose: Thrombosis and thromboembolic occlusions of blood vessels are a major complication in various peripheral vascular diseases. The agents for the inhibition of platelet function are recognized as key tools in the treatment of atherothrombosis. Therefore, it became a mainstay medication for a wide range of vascular diseases. Polyozellin (POZ), a major constituent of an edible mushroom Poly...
متن کاملSlow tight-binding inhibition of prolyl endopeptidase by benzyloxycarbonyl-prolyl-prolinal.
Prolyl endopeptidase is a serine proteinase that specifically cleaves peptides on the carboxy side of proline residues. Wilk & Orlowski [(1983) J. Neurochem. 41, 69-75] have shown that benzyloxycarbonyl-prolyl-prolinal (Z-prolyl-prolinal) is a potent inhibitor of prolyl endopeptidase. We show that Z-prolyl-prolinal is a slow-binding inhibitor of mouse brain prolyl endopeptidase with Ki 0.35 +/-...
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Non-peptidyl postatin analogues, (S)-N-substituted-2-[2-(1-acylpyrrolidinyl)]-2-oxoacetamides were synthesized and examined for their inhibitory activity against prolyl endopeptidase and cathepsin B in vitro. Many compounds showed stronger activity than natural poststatin, a pentapeptide. Among them, (S)-N-cyclohexyl-2-oxo-2-[2-(1-(3-phenoxybenzoyl)pyrrolidinyl)]ace tamide (22) and (S)-N-cycloh...
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 50 9 شماره
صفحات -
تاریخ انتشار 1997